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GeldanamycinCatalog No. A11025

Quick Overview

Geldanamycin binds to the ATP site of Hsp90 (Kd = 1.2 μM) and inhibits its chaperone activity.
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Product Information
Catalog Num A11025
M. Wt 560.6
Formula C29H40N2O9
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 30562-34-6
Synonyms N/A
Chemical Name 9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate
SMILES Code C[[email protected]]1C[[email protected]@H]([[email protected]@H]([[email protected]](/C=C(/[[email protected]@H]([[email protected]](/C=C/C=C(/C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)\C)OC)OC(=O)N)\C)C)O)OC

Biological activity
Geldanamycin binds to the ATP site of Hsp90 (Kd = 1.2 μM) and inhibits its chaperone activity.
p185 HSP90 (N-terminal domain) HSP90
70 nM0.78 μM(Kd)1.2 μM(Kd)
Solubility (25C)* In vitro DMSO 100 mg/mL heating (178.36 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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