Quick Overview

GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.
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GSK1120212 (JTP-74057, Trametinib)

Product Information
Catalog Num A11029
M. Wt 615.4
Formula C26H23FIN5O4
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 871700-17-3
Synonyms GSK-1120212, GSK212, Trametinib
Chemical Name N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide
SMILES Code CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5

Biological activity
Introduction
GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.
Targets
MEK1 (Cell-free assay) MEK2 (Cell-free assay)
0.92 nM1.8 nM
Solubility
Solubility (25C) * In vitro DMSO 100 mg/mL heating (162.49 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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