GSK690693Catalog No. A11030

Quick Overview

GSK690693 is a novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor.
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GSK690693

Product Information
Catalog Num A11030
M. Wt 425.5
Formula C21H27N7O3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 937174-76-0
Synonyms GSK-690693
Chemical Name 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol
SMILES Code CCN1C2=C(C(=NC=C2OC[C@H]3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N

Biological activity
Introduction
GSK690693 is a novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor.
Targets
Target Value
Akt1IC50: 2nM
PKCηIC50: 2nM
PKCθIC50: 2nM
PrkXIC50: 5nM
Akt3IC50: 9nM
Akt2IC50: 13nM
PKCδIC50: 14nM
PKCβIC50: 19nM
PKCεIC50: 21nM
PKAIC50: 24nM
PKG1βIC50: 33nM
Solubility
Solubility (25C) * In vitro DMSO 39 mg/mL (91.66 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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High Purity Kinase Inhibitors on Signaling Pathways

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