MG-132Catalog No. A11043

Quick Overview

MG-132 is a potent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 μM).
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MG-132

Product Information
Catalog Num A11043
M. Wt 475.6
Formula C26H41N3O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 133407-82-6
Synonyms Z-Leu-Leu-Leu-CHO, Z-LLL-CHO, MG132
Chemical Name N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide
SMILES Code CC(C)C[[email protected]@H](C=O)NC(=O)[[email protected]](CC(C)C)NC(=O)[[email protected]](CC(C)C)NC(=O)OCC1=CC=CC=C1

Biological activity
Introduction
MG-132 is a potent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 μM).
Targets
Proteasome (Cell-free assay)
100 nM
Solubility
Solubility (25C) * In vitro DMSO 95 mg/mL (199.73 mM)
Water <1 mg/mL (<1 mM)
Ethanol 95 mg/mL (199.73 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80, pH 4 6 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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