BMS-536924Catalog No. A11054

Quick Overview

BMS-536924 is an effective inhibitor of IGF-IR, causing a reversion of an IGF-IR - mediated transformed phenotype.
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BMS-536924

Product Information
Catalog Num A11054
M. Wt 480.0
Formula C25H26ClN5O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 468740-43-4
Synonyms BMS536924
Chemical Name (R)-4-(3-(3-chlorophenyl)-3-hydroxypropyl)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
SMILES Code CC1=CC(=CC2=C1N/C(=C/3\C(=CC=NC3=O)NC[[email protected]](C4=CC(=CC=C4)Cl)O)/N2)N5CCOCC5

Biological activity
Introduction
BMS-536924 is an effective inhibitor of IGF-IR, causing a reversion of an IGF-IR - mediated transformed phenotype.
Targets
Target Value
Insulin ReceptorIC50: 73nM
IGF-1RIC50: 100nM
FAKIC50: 150nM
MEKIC50: 182nM
LCKIC50: 341nM
CDK2/CyclinEIC50: >1μM
VEGFR2IC50: 1.4μM
EGFIC50: 1.6μM
MetIC50: 4.87μM
MAPK2IC50: ~5μM
MAPK1IC50: >5μM
Akt1IC50: >5μM
PDGFRIC50: >5μM
HER2IC50: 17.1μM
Solubility
Solubility (25C) * In vitro DMSO 96 mg/mL (200.01 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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