OSI-027Catalog No. A11056

Quick Overview

OSI-027 is a potent, selective and orally bioavailable mTOR kinase inhibitor that inhibits the kinase activity associated with both the TORC1 and TORC2 complexes of mTOR.
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OSI-027

Product Information
Catalog Num A11056
M. Wt 406.4
Formula C21H22N6O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 936890-98-1
Synonyms OSI027
Chemical Name 4-(4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid hydrochloride
SMILES Code COC1=CC=CC2=C/C(=C/3\C4=C(N=CNN4C(=N3)C5CCC(CC5)C(=O)O)N)/N=C21

Biological activity
Introduction
OSI-027 is a potent, selective and orally bioavailable mTOR kinase inhibitor that inhibits the kinase activity associated with both the TORC1 and TORC2 complexes of mTOR.
Targets
Target Value
mTORIC50: 4nM
mTORC1IC50: 22nM
mTORC2IC50: 65nM
PI3KγIC50: 0.42μM
DNA-PKIC50: 1.0μM
PI3KαIC50: 1.3μM
C-RafIC50: 1.6μM
YES1IC50: 2.8μM
EphA2IC50: 4.5μM
BTKIC50: 5.0μM
LCKIC50: 9.5μM
ACK1IC50: >10μM
p38αIC50: 10.6μM
KDRIC50: 19.0μM
PI3KβIC50: >30μM
IGF-1RIC50: >30μM
Insulin ReceptorIC50: >30μM
PDK-1IC50: >30μM
PKAIC50: >30μM
EGFR/ErbB1IC50: >30μM
MST1RIC50: >30μM
SrcIC50: >30μM
MEK1IC50: >30μM
FynIC50: >30μM
Solubility
Solubility (25C) * In vitro DMSO 18 mg/mL (44.28 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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