CX-4945 (Silmitasertib)Catalog No. A11060

Quick Overview

CX-4945 is a potent and selective orally bioavailable small molecule inhibitor of CK2 that inhibits human umbilical vein endothelial cell migration, tube formation, and blocks CK2-dependent hypoxia-induced factor 1 alpha (HIF-1α) transcription in cancer cells.
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CX-4945 (Silmitasertib)

Product Information
Catalog Num A11060
M. Wt 349.8
Formula C19H12ClN3O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1009820-21-6
Synonyms Silmitasertib, CX 4945, CX4945
Chemical Name 5-[(3-Chlorophenyl)amino]benzo[c]-2,6-naphthyridine-8-carboxylic acid
SMILES Code C1=CC(=CC(=C1)Cl)NC2=C3C=CN=CC3=C4C=CC(=CC4=N2)C(=O)O

Biological activity
Introduction
CX-4945 is a potent and selective orally bioavailable small molecule inhibitor of CK2 that inhibits human umbilical vein endothelial cell migration, tube formation, and blocks CK2-dependent hypoxia-induced factor 1 alpha (HIF-1α) transcription in cancer cells.
Targets
CK2 (Cell-free assay)
1 nM
Solubility
Solubility (25C)* In vitro DMSO 16 mg/mL (45.74 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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