SB 415286 Catalog No. A11061

Quick Overview

SB 415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM.
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SB 415286

Product Information
Catalog Num A11061
M. Wt 359.7
Formula C16H10ClN3O5
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 264218-23-7
Synonyms SB-415286, SB415286
Chemical Name 3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
SMILES Code C1=CC=C(C(=C1)C2=C(C(=O)NC2=O)NC3=CC(=C(C=C3)O)Cl)[N+](=O)[O-]

Biological activity
Introduction
SB 415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM.
Targets
GSK-3α GSK-3β
78 nM~78 nM
Solubility
Solubility (25C)* In vitro DMSO 72 mg/mL (200.15 mM)
Water <1 mg/mL (<1 mM)
Ethanol 72 mg/mL (200.15 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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