AMG 900Catalog No. A11066

Quick Overview

AMG 900 is a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines.
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AMG 900

Product Information
Catalog Num A11066
M. Wt 503.6
Formula C28H21N7OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 945595-80-2
Synonyms AMG-900, AMG900
Chemical Name N-[4-[[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine
SMILES Code CC1=CSC(=C1)C2=NN=C(C3=CC=CC=C32)NC4=CC=C(C=C4)OC5=C(C=CC=N5)C6=NC(=NC=C6)N

Biological activity
Introduction
AMG 900 is a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines.
Targets
Target Value
AuroraCIC50: 1nM
AuroraBIC50: 4nM
AuroraAIC50: 5nM
p38αIC50: 53nM
TYK2IC50: 220nM
JNK2IC50: 520nM
MetIC50: 550nM
Tie-2IC50: 650nM
Solubility
Solubility (25C) * In vitro DMSO 100 mg/mL (198.57 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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