TAK-901Catalog No. A11067

Quick Overview

TAK-901 is a novel inhibitor of Aurora A/B with IC50 of 21 nM/15 nM. It is not a potent inhibitor of cellular JAK2, c-Src or Abl. Phase 1.
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TAK-901

Product Information
Catalog Num A11067
M. Wt 504.6
Formula C28H32N4O3S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 934541-31-8
Synonyms TAK901
Chemical Name 5-[3-(Ethylsulfonyl)phenyl]-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-9H-pyrido[2,3-b]indole-7-carboxamide
SMILES Code CCS(=O)(=O)C1=CC=CC(=C1)C2=CC(=C(C3=C2C4=CC(=CN=C4N3)C)C)C(=O)NC5CCN(CC5)C

Biological activity
Introduction
TAK-901 is a novel inhibitor of Aurora A/B with IC50 of 21 nM/15 nM. It is not a potent inhibitor of cellular JAK2, c-Src or Abl. Phase 1.
Targets
Target Value
JAK3IC50: 1.2nM
c-SrcIC50: 1.3nM
CLK2IC50: <2.0nM
FGRIC50: <2.0nM
YES1IC50: <2.0nM
LRRK2IC50: 3.0nM
FLT3IC50: 5.0nM
FynIC50: 5.3nM
ARGIC50: 5.6nM
AxlIC50: 5.8nM
HckIC50: 5.8nM
SNF1LK2IC50: 6.0nM
AblIC50: 6.4nM
RETIC50: 6.5nM
TrkAIC50: 6.7nM
LCKIC50: 6.8nM
PTK5IC50: 7.1nM
FmsIC50: 7.2nM
FGFR2IC50: 7.3nM
EphB1IC50: 8.9nM
Abl(T315I)IC50: 9.0nM
EphA1IC50: 9.1nM
ARK5IC50: 9.1nM
ITKIC50: 12nM
ALK2IC50: 13nM
CDK7IC50: 14nM
BLKIC50: 14nM
AuroraB-INCENPIC50: 15nM
JAK2IC50: 17nM
EphB2IC50: 18nM
AuroraA-TPX2IC50: 21nM
STK16IC50: 24nM
EphA2IC50: 24nM
BRKIC50: 25nM
EphB4IC50: 27nM
TNK2IC50: 27nM
FGFR1IC50: 28nM
EphA4IC50: 31nM
STK33IC50: 35nM
CLK1IC50: 45nM
AMPKIC50: 46nM
FESIC50: 48nM
SLKIC50: 49nM
Chk2IC50: 50nM
TYK2IC50: 54nM
BTKIC50: 55nM
FAK2IC50: 55nM
c-KitIC50: 58nM
VEGFR2IC50: 60nM
FGFR3IC50: 65nM
ALK5IC50: 78nM
MAP3K9IC50: 80nM
CLK3IC50: 88nM
JAK1IC50: 93nM
Solubility
Solubility (25C)* In vitro DMSO 101 mg/mL (200.14 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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