PF-04929113 (SNX-5422)Catalog No. A11074

Quick Overview

PF-04929113 (SNX-5422) is orally bioavailable heat shock protein 90 (Hsp90) inhibitor.
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PF-04929113 (SNX-5422)

Product Information
Catalog Num A11074
M. Wt 521.5
Formula C25H30F3N5O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 908115-27-5
Synonyms PF04929113, SNX5422
Chemical Name (1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl 2-aminoacetate
SMILES Code CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)OC(=O)CN)C(F)(F)F)C

Biological activity
Introduction
PF-04929113 (SNX-5422) is orally bioavailable heat shock protein 90 (Hsp90) inhibitor.
Targets
HER2 HSP90
37 nM41 nM(Kd)
Solubility
Solubility (25C) * In vitro DMSO 104 mg/mL (199.41 mM)
Water <1 mg/mL (<1 mM)
Ethanol 5 mg/mL (9.58 mM)
In vivo 0.5% CMC/0.25% Tween 80 25 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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