AS-252424Catalog No. A11099

Quick Overview

AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. It inhibits human recombinant PI3Kγ, α, β, and δ with IC50 values of 30, 940, 20,000, and 20,000 nM respectively.
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AS-252424

Product Information
Catalog Num A11099
M. Wt 305.3
Formula C14H8FNO4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 900515-16-4
Synonyms AS252424
Chemical Name 5-[5-(4-fluoro-2-hydroxy-phenyl)-furan-2-ylmethylene]-thiazolidine-2,4-dione
SMILES Code C1=CC(=C(C=C1F)O)C2=CC=C(O2)/C=C\3/C(=O)NC(=O)S3

Biological activity
Introduction
AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. It inhibits human recombinant PI3Kγ, α, β, and δ with IC50 values of 30, 940, 20,000, and 20,000 nM respectively.
Targets
Casein Kinase 2 (Cell-free assay) PI3Kγ (Cell-free assay) PI3Kα (Cell-free assay)
20 nM33 nM935 nM
Solubility
Solubility (25C) * In vitro DMSO 61 mg/mL (199.81 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC/0.25% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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