CUDC-907Catalog No. A11153

Quick Overview

CUDC-907 is a single small molecule inhibitor that targets both PI3K and HDAC. CUDC-907 is more efficacious than either a single PI3K or HDAC inhibitor reference compound or a combination of the two single agents at maximally tolerated doses.
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CUDC-907

Product Information
Catalog Num A11153
M. Wt 508.6
Formula C23H24N8O4S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1339928-25-4
Synonyms CUDC907
Chemical Name N-hydroxy-2-(((2-(6-methoxypyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxamide
SMILES Code CN(CC1=CC2=C(S1)C(=NC(=N2)C3=CN=C(C=C3)OC)N4CCOCC4)C5=NC=C(C=N5)C(=O)NO

Biological activity
Introduction
CUDC-907 is a single small molecule inhibitor that targets both PI3K and HDAC. CUDC-907 is more efficacious than either a single PI3K or HDAC inhibitor reference compound or a combination of the two single agents at maximally tolerated doses.
Targets
Target Value
HDAC1IC50: 1.7nM
HDAC3IC50: 1.8nM
HDAC10IC50: 2.8nM
HDAC2IC50: 5.0nM
HDAC11IC50: 5.4nM
PI3KαIC50: 19nM
HDAC6IC50: 27nM
PI3KδIC50: 39nM
PI3KβIC50: 54nM
HDAC8IC50: 191nM
PI3KγIC50: 311nM
HDAC4IC50: 409nM
HDAC7IC50: 426nM
HDAC9IC50: 554nM
HDAC5IC50: 674nM
Solubility
Solubility (25C)* In vitro DMSO 102 mg/mL (200.57 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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