R547Catalog No. A11190

Quick Overview

R547 is a novel, selective inhibitor of cell cycle and transcriptional cyclin dependent kinases (CDKs) (Ki = 1, 3, and 1 nM for CDK1, CDK2, and CDK4, respectively) with excellent in vitro cellular potency that inhibits the growth of various human tumor cell lines.

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R547

Product Information
Catalog Num A11190
M. Wt 441.45
Formula C18H21F2N5O4S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 741713-40-6
Synonyms R-547
Chemical Name [4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone
SMILES Code COC1=C(C(=C(C=C1)F)F)C(=O)C2=CN=C(N=C2N)NC3CCN(CC3)S(=O)(=O)C

Biological activity
Introduction

R547 is a novel, selective inhibitor of cell cycle and transcriptional cyclin dependent kinases (CDKs) (Ki = 1, 3, and 1 nM for CDK1, CDK2, and CDK4, respectively) with excellent in vitro cellular potency that inhibits the growth of various human tumor cell lines.

Targets
Target Value
CDK4/CyclinD1ki: 1nM
CDK1/CyclinBki: 2nM
CDK2/CyclinEki: 3nM
PKAki: >5μM
PKBki: >5μM
PKCαki: >5μM
PKCβki: >5μM
Fynki: >5μM
EphB3ki: >5μM
SGKki: >5μM
KDRki: >5μM
FGFRki: >5μM
EGFRki: >5μM
PDGFRki: >5μM
IGFRki: >5μM
Srcki: >5μM
FAKki: >5μM
AuroraAki: >5μM
GSK-3βki: 8μM
p38ki: >50μM
MAPK2ki: >50μM
Solubility
Solubility (25C) * In vitro DMSO 60 mg/mL (135.91 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% hydroxyethyl cellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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