EMD-1214063Catalog No. A11257

Quick Overview

EMD-1214063 is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. It binds to MET tyrosine kinase and disrupts MET signal transduction pathways, which may induce apoptosis in tumor cells overexpressing this kinase.
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EMD-1214063

Product Information
Catalog Num A11257
M. Wt 492.6
Formula C29H28N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1100598-32-0
Synonyms EMD1214063
Chemical Name 3-[1,6-Dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]benzonitrile
SMILES Code CN1CCC(CC1)COC2=CN=C(N=C2)C3=CC(=CC=C3)CN4C(=O)C=CC(=N4)C5=CC=CC(=C5)C#N

Biological activity
Introduction
EMD-1214063 is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. It binds to MET tyrosine kinase and disrupts MET signal transduction pathways, which may induce apoptosis in tumor cells overexpressing this kinase.
Targets
Target Value
c-MetIC50: 4nM
IRAK4IC50: 615nM
TrkAIC50: 1.017μM
AxlIC50: 1.566μM
IRAK1IC50: 2.037μM
MerIC50: 2.272μM
TrkBIC50: 5.716μM
RONIC50: >10μM
Solubility
Solubility (25C)* In vitro DMSO 5 mg/mL heating (10.15 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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