CP-673451Catalog No. A11350

Quick Overview

CP 673451 is a potent PDGFR-β inhibitor with an IC50 of 1 nM.
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CP-673451

Product Information
Catalog Num A11350
M. Wt 417.5
Formula C24H27N5O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 343787-29-1
Synonyms CP673451
Chemical Name 1-(2-(5-(2-methoxyethoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine
SMILES Code COCCOC1=CC2=C(C=C1)N(C=N2)C3=NC4=C(C=CC=C4N5CCC(CC5)N)C=C3

Biological activity
Introduction
CP 673451 is a potent PDGFR-β inhibitor with an IC50 of 1 nM.
Targets
Target Value
PDGFRβIC50: 1nM
PDGFRαIC50: 10nM
c-KitIC50: 252nM
VEGFR1IC50: 450nM
VEGFR2IC50: 450nM
LCKIC50: >1μM
SrcIC50: >2μM
v-AblIC50: >5μM
Tie-2IC50: >5μM
bFGFRIC50: >5μM
EGFRIC50: >10μM
ErbB2IC50: >10μM
c-MetIC50: >10μM
IGF-1RIC50: >10μM
Solubility
Solubility (25C)* In vitro DMSO 28 mg/mL heating (67.06 mM)
Water <1 mg/mL (<1 mM)
Ethanol 4 mg/mL (9.58 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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