CB 300919Catalog No. A11359

Quick Overview

CB 300919 is a potential therapy for ovarian cancer. Preclinical data showed that this quinazoline-based compound CB 300919 has a continuous exposure (96 h) growth inhibition IC50 value of 2 nM in human CH1 ovarian tumor xenograft
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CB 300919

Product Information
Catalog Num A11359
M. Wt 584.11
Formula C32H34ClN7O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 289715-28-2
Synonyms CB300919, CB-300919
Chemical Name 4-[[[7-Chloro-3,4-dihydro-3-methyl-2-[(4-methyl-1-piperazinyl)methyl]-4-oxo-6-quinazolinyl]methyl]-2-propyn-1-ylamino]-N-(3-pyridinylmethyl)benzamide
SMILES Code CN1CCN(CC1)CC2=NC3=CC(=C(C=C3C(=O)N2C)CN(CC#C)C4=CC=C(C=C4)C(=O)NCC5=CN=CC=C5)Cl

Biological activity
Introduction
CB 300919 is a potential therapy for ovarian cancer. Preclinical data showed that this quinazoline-based compound CB 300919 has a continuous exposure (96 h) growth inhibition IC50 value of 2 nM in human CH1 ovarian tumor xenograft
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