Evacetrapib (LY2484595)Catalog No. A11397

Quick Overview

Evacetrapib (LY2484595) is a drug that inhibits cholesterylester transfer protein, which transfers and thereby increases high-density lipoprotein and lowers low-density lipoprotein.
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Evacetrapib (LY2484595)

Product Information
Catalog Num A11397
M. Wt 638.65
Formula C31H36F6N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1186486-62-3
Synonyms LY2484595, LY-2484595, LY 2484595
Chemical Name trans-4-[[(5S)-5-[[[3,5-Bis(trifluoromethyl)phenyl]methyl](2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]cyclohexanecarboxylic acid
SMILES Code CC1=CC(=C2C(=C1)[C@H](CCCN2CC3CCC(CC3)C(=O)O)N(CC4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F)C5=NN(N=N5)C)C

Biological activity
Introduction
Evacetrapib (LY2484595) is a drug that inhibits cholesterylester transfer protein, which transfers and thereby increases high-density lipoprotein and lowers low-density lipoprotein.
Targets
CETP
5.5 nM
Solubility
Solubility (25C) * In vitro DMSO 12.8 mg/mL (20.04 mM)
Water <1 mg/mL (<1 mM)
Ethanol 12.8 mg/mL (20.04 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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