AG-1024 (Tyrphostin)Catalog No. A11400

Quick Overview

AG-1024 (Tyrphostin) is a specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Exhibits lower IC50 values for IGF-1 than for the insulin receptor. Also inhibits insulin-stimulated cellular proliferation.
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AG-1024 (Tyrphostin)

Product Information
Catalog Num A11400
M. Wt 305.2
Formula C14H13BrN2O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 65678-07-1
Synonyms AG1024
Chemical Name [3-bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene
SMILES Code CC(C)(C)C1=C(C(=CC(=C1)C=C(C#N)C#N)Br)O

Biological activity
Introduction
AG-1024 (Tyrphostin) is a specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Exhibits lower IC50 values for IGF-1 than for the insulin receptor. Also inhibits insulin-stimulated cellular proliferation.
Targets
IGF-1R Insulin Receptor
7 μM57 μM
Solubility
Solubility (25C) * In vitro DMSO 61 mg/mL (199.88 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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