INK 128 (MLN0128)Catalog No. A11461

Quick Overview

INK 128 is a TORC1/2 inhibitor, is also an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity.
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INK 128 (MLN0128)

Product Information
Catalog Num A11461
M. Wt 309.3
Formula C15H15N7O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1224844-38-5
Synonyms INK128, INK-128
Chemical Name 3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
SMILES Code CC(C)N1C2=C(C(=N1)C3=CC4=C(C=C3)OC(=N4)N)C(=NC=N2)N

Biological activity
Introduction
INK 128 is a TORC1/2 inhibitor, is also an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity.
Targets
Target Value
mTORki: 1.4nM
mTORki: 1.4nM
PI3KαIC50: 219nM
PI3KγIC50: 221nM
PI3KδIC50: 230nM
PI3KβIC50: 5293nM
Solubility
Solubility (25C) * In vitro DMSO 62 mg/mL (200.43 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (6.46 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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