Pazopanib (GW-786034)Catalog No. A11518

Quick Overview

Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.
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Pazopanib (GW-786034)

Product Information
Catalog Num A11518
M. Wt 437.5
Formula C21H23N7O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 444731-52-6
Synonyms GW 786034, Votrient,GW786034
Chemical Name 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzolsulfonamide
SMILES Code CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N

Biological activity
Introduction
Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.
Targets
Target Value
VEGFR1IC50: 10nM
VEGFR2IC50: 30nM
VEGFR3IC50: 47nM
FGFRIC50: 74nM
PDGFRIC50: 84nM
c-KitIC50: 140nM
c-FmsIC50: 146nM
Solubility
Solubility (25C)* In vitro DMSO 88 mg/mL (201.13 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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