SB 239063Catalog No. A11562

Quick Overview

SB 239063 is a potent and selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. SB 239063 reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo.
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SB 239063

Product Information
Catalog Num A11562
M. Wt 368.4
Formula C20H21FN4O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 193551-21-2
Synonyms SB239063, SB-239063
Chemical Name trans-1-(4-Hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole
SMILES Code COC1=NC=CC(=N1)C2=C(N=CN2C3CCC(CC3)O)C4=CC=C(C=C4)F

Biological activity
Introduction
SB 239063 is a potent and selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. SB 239063 reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo.
Targets
p38α p38β
44 nM44 nM
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High Purity Kinase Inhibitors on Signaling Pathways

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