Sitaxsentan sodium (TBC-11251)Catalog No. A11564

Quick Overview

Sitaxentan sodium (TBC-11251) is a selective endothelin receptor-A antagonist with IC50 and Ki of 1.4 nM and 0.43 nM, respectively.
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Sitaxsentan sodium (TBC-11251)

Product Information
Catalog Num A11564
M. Wt 476.89
Formula C18H14ClN2NaO6S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 210421-74-2
Synonyms N/A
Chemical Name Sodium (4-chloro-3-methyl-1,2-oxazol-5-yl)-[2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]thiophen-3-yl]sulfonylazanide
SMILES Code CC1=CC2=C(C=C1CC(=O)C3=C(C=CS3)S(=O)(=O)[N-]C4=C(C(=NO4)C)Cl)OCO2.[Na+]

Biological activity
Introduction
Sitaxentan sodium (TBC-11251) is a selective endothelin receptor-A antagonist with IC50 and Ki of 1.4 nM and 0.43 nM, respectively.
Targets
ET-A ET-A
0.43 nM(Ki)1.4 nM
Solubility
Solubility (25C)* In vitro DMSO 40 mg/mL (83.87 mM)
Water <1 mg/mL (<1 mM)
Ethanol 20 mg/mL (41.93 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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