T0070907Catalog No. A11588

Quick Overview

T0070907 was identified as a potent and selective PPARgamma antagonist. With an apparent binding affinity (concentration at 50% inhibition of [(3)H]rosiglitazone binding or IC(50)) of 1 nm, T0070907 covalently modifies PPARgamma on cysteine 313 in helix 3 of human PPARgamma2.
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T0070907

Product Information
Catalog Num A11588
M. Wt 277.66
Formula C12H8ClN3O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 313516-66-4
Synonyms T 0070907
Chemical Name 2-chloro-5-nitro-N-(pyridin-4-yl)benzamide
SMILES Code ClC1=CC=C([N+]([O-])=O)C=C1C(NC2=CC=NC=C2)=O

Biological activity
Introduction
T0070907 was identified as a potent and selective PPARgamma antagonist. With an apparent binding affinity (concentration at 50% inhibition of [(3)H]rosiglitazone binding or IC(50)) of 1 nm, T0070907 covalently modifies PPARgamma on cysteine 313 in helix 3 of human PPARgamma2.
Targets
PPARγ (Cell-free assay) PPARα (Cell-free assay) PPARδ (Cell-free assay)
1 nM0.85 μM1.8 μM
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High Purity Kinase Inhibitors on Signaling Pathways

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