LY2811376Catalog No. A11776

Quick Overview

LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals.
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LY2811376

Product Information
Catalog Num A11776
M. Wt 320.4
Formula C15H14F2N4S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1194044-20-6
Synonyms LY 2811376, LY-2811376
Chemical Name (S)-4-(2,4-difluoro-5-pyrimidin-5-yl-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]thiazin-2-ylamine
SMILES Code C[[email protected]]1(CCSC(=N1)N)C2=C(C=C(C(=C2)C3=CN=CN=C3)F)F

Biological activity
Introduction
LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals.
Targets
BACE1
239 nM-249 nM~300 nM(EC50)
Solubility
Solubility (25C) * In vitro DMSO 16 mg/mL (49.94 mM)
Water <1 mg/mL (<1 mM)
Ethanol 64 mg/mL (199.77 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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