Tenovin-6Catalog No. A12305

Quick Overview

Tenovin-6 is a analog of tenovin-1. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 uM, respectively.
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Tenovin-6

Product Information
Catalog Num A12305
M. Wt 454.6
Formula C25H34N4O2S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1011557-82-6
Synonyms Tenovin6, Tenovin 6
Chemical Name N-?[[[4-?[[5-?(dimethylamino)-?1-?oxopentyl]amino]phenyl]amino]thioxomethyl]-?4-?(1,?1-?dimethylethyl)-?benzamide
SMILES Code CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C

Biological activity
Introduction
Tenovin-6 is a analog of tenovin-1. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 uM, respectively.
Targets
p53 SIRT2 SIRT1 SIRT3
N/A10 μM21 μM67 μM
Solubility
Solubility (25C)* In vitro DMSO 98 mg/mL (215.55 mM)
Water 98 mg/mL heating (215.55 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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