PP1Catalog No. A12724

Quick Overview

PP1 is a potent inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl
Products are for laboratory research use only. Not for human use. We do not sell to patients.

PP1

Product Information
Catalog Num A12724
M. Wt 281.36
Formula C16H19N5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 172889-26-8
Synonyms PP-1, PP 1
Chemical Name 1-(1,1-Dimethylethyl)-1-(4-methylph?enyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
SMILES Code CC1=CC=C(C=C1)C2=NN(C3=C2C(=NC=N3)N)C(C)(C)C

Biological activity
Introduction
PP1 is a potent inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl
Targets
Target Value
LCKIC50: 5nM
FynIC50: 6nM
KitIC50: ~75nM
EGFRIC50: 250nM
Bcr-AblIC50: 1μM
JAK2IC50: >50μM
ZAP70IC50: >100μM
Solubility
Solubility (25C)* In vitro DMSO 4 mg/mL (14.21 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
Adooq Bioscience has Satisfaction Guarantee return policy. You may return/exchange any items within 365 days from the original purchase date if you are not satisfied with your purchase, either for protocol related or product related problems.

>>This offer is only valid for products purchased directly from Adooq and its authorized distributors.

>>Prior to returning any items, please contact the Customer Service ([email protected]) to obtain an Return/Exchange Authorization. Items returned without prior authorization may not be accepted. Any items returned to Adooq should be in the original packaging and in the same condition as originally purchased.


Website: www.adooq.com
Order: [email protected]
Phone:
(866)930-6790 (US & Canada)
+1-323-389-9269 (Outside of US & CAN)
Fax:
(866)333-9607 (US & Canada)
+1-323-606-8156 (Outside of US & CAN)
Support:
[email protected]

High Purity Kinase Inhibitors on Signaling Pathways

Copyright© 2006-2017 Adooq BioScience LLC, All Rights Reserved.
4000 Barranca Parkway, Suite 250, Irvine, CA 92604 USA. Tel: 855-930-6790