SC-514Catalog No. A12746

Quick Overview

SC-514 is an orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK.
Products are for laboratory research use only. Not for human use. We do not sell to patients.

SC-514

Product Information
Catalog Num A12746
M. Wt 224.3
Formula C9H8N2OS2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 354812-17-2
Synonyms SC514, SC 514
Chemical Name 4-Amino-[2',3'-bithiophene]-5-carboxa?mide
SMILES Code C1=CSC=C1C2=CC(=C(S2)C(=O)N)N

Biological activity
Introduction
SC-514 is an orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK.
Targets
Target Value
IKK2IC50: 3μM-12μM
CDK2/CyclinAIC50: 61μM
AUR2IC50: 71μM
PRAKIC50: 75μM
p38αIC50: >100μM
p38βIC50: >100μM
p38γIC50: >100μM
p38δIC50: >100μM
ERK2IC50: >100μM
GSK-3IC50: >100μM
NIM1IC50: >100μM
Chk1IC50: >100μM
PAK5IC50: >100μM
PKAIC50: >100μM
PKCβIC50: >100μM
LynIC50: >100μM
FGFR1IC50: >100μM
EGFRIC50: >100μM
LCKIC50: >100μM
c-AblIC50: >100μM
MSKIC50: 123μM
JNK1IC50: >200μM
JNK2IC50: >200μM
JNK3IC50: >200μM
MK2IC50: >200μM
MK3IC50: >200μM
RSKBIC50: >200μM
MKK7IC50: >200μM
Solubility
Solubility (25C)* In vitro DMSO 45 mg/mL (200.62 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
Adooq Bioscience has Satisfaction Guarantee return policy. You may return/exchange any items within 365 days from the original purchase date if you are not satisfied with your purchase, either for protocol related or product related problems.

>>This offer is only valid for products purchased directly from Adooq and its authorized distributors.

>>Prior to returning any items, please contact the Customer Service ([email protected]) to obtain an Return/Exchange Authorization. Items returned without prior authorization may not be accepted. Any items returned to Adooq should be in the original packaging and in the same condition as originally purchased.


Website: www.adooq.com
Order: [email protected]
Phone:
(866)930-6790 (US & Canada)
+1-323-389-9269 (Outside of US & CAN)
Fax:
(866)333-9607 (US & Canada)
+1-323-606-8156 (Outside of US & CAN)
Support:
[email protected]

High Purity Kinase Inhibitors on Signaling Pathways

Copyright© 2006-2017 Adooq BioScience LLC, All Rights Reserved.
4000 Barranca Parkway, Suite 250, Irvine, CA 92604 USA. Tel: 855-930-6790