JZL184Catalog No. A12747

Quick Overview

JZL184 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM).
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JZL184

Product Information
Catalog Num A12747
M. Wt 520.49
Formula C27H24N2O9
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1101854-58-3
Synonyms JZL-184, JZL 184
Chemical Name 4-[Bis(1,3-benzodioxol-5-yl)hydroxy?methyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester
SMILES Code C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC6=CC=C(C=C6)[N+](=O)[O-]

Biological activity
Introduction
JZL184 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM).
Solubility
Solubility (25C) * In vitro DMSO 100 mg/mL (192.12 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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