CO-1686 (Rociletinib, AVL-301)Catalog No. A13028

Quick Overview

CO-1686 is a novel, oral, targeted covalent (irreversible) inhibitor of the cancer-causing mutant forms of epidermal growth factor receptor (EGFR) currently being studied for the treatment of non-small cell lung cancer (NSCLC).
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CO-1686 (Rociletinib, AVL-301)

Product Information
Catalog Num A13028
M. Wt 555.55
Formula C27H28F3N7O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1374640-70-6
Synonyms CO1686; AVL-301; CNX-419 ;AVL 301; AVL301; CNX419
Chemical Name N-(3-((2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide
SMILES Code CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F)OC

Biological activity
Introduction
CO-1686 is a novel, oral, targeted covalent (irreversible) inhibitor of the cancer-causing mutant forms of epidermal growth factor receptor (EGFR) currently being studied for the treatment of non-small cell lung cancer (NSCLC).
Solubility
Solubility (25C) * In vitro DMSO 100 mg/mL (180 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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