PHA 408Catalog No. A13108

Quick Overview

PHA 408 is a potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50: 40 nM), which binds IKK-2 tightly with a relatively slow off rate; highly recommended tool to investigate the mechanisms by which IKK-2 regulates NF-KB signaling.
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PHA 408

Product Information
Catalog Num A13108
M. Wt 560.02
Formula C29H27ClFN7O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 503555-55-3
Synonyms PHA-408, PHA408
Chemical Name 8-(5-chloro-2-(4-methylpiperazin-1-yl)isonicotinamido)-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide
SMILES Code CN1CCN(CC1)C2=NC=C(C(=C2)C(=O)NC3=CC4=C(CCC5=C4N(N=C5C(=O)N)C6=CC=C(C=C6)F)C=C3)Cl

Biological activity
Introduction
PHA 408 is a potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50: 40 nM), which binds IKK-2 tightly with a relatively slow off rate; highly recommended tool to investigate the mechanisms by which IKK-2 regulates NF-KB signaling.
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High Purity Kinase Inhibitors on Signaling Pathways

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