GSK343Catalog No. A13114

Quick Overview

GSK343 is a potent histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor (IC= 4 nM). Diplays 1000-fold selectivity for other HMTs except EZH1 (60-fold selectivity). GSK343 inhibits H3K27 methylation in HCC1806 cells with an IC of <200nM (measured by immunofluorescence).
Products are for laboratory research use only. Not for human use. We do not sell to patients.

GSK343

Product Information
Catalog Num A13114
M. Wt 541.69
Formula C31H39N7O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1346704-33-3
Synonyms GSK-343, GSK 343
Chemical Name 1-isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-6-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole-4-carboxamide.
SMILES Code CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC(=NC=C4)N5CCN(CC5)C)C(C)C

Biological activity
Introduction
GSK343 is a potent histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor (IC= 4 nM). Diplays 1000-fold selectivity for other HMTs except EZH1 (60-fold selectivity). GSK343 inhibits H3K27 methylation in HCC1806 cells with an IC of <200nM (measured by immunofluorescence).
Targets
EZH2 (Cell-free assay) EZH1 (Cell-free assay)
4 nM240 nM
Solubility
Solubility (25C)* In vitro DMSO 1 mg/mL heating (1.84 mM)
Water <1 mg/mL (<1 mM)
Ethanol 4 mg/mL (7.38 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
Adooq Bioscience has Satisfaction Guarantee return policy. You may return/exchange any items within 365 days from the original purchase date if you are not satisfied with your purchase, either for protocol related or product related problems.

>>This offer is only valid for products purchased directly from Adooq and its authorized distributors.

>>Prior to returning any items, please contact the Customer Service ([email protected]) to obtain an Return/Exchange Authorization. Items returned without prior authorization may not be accepted. Any items returned to Adooq should be in the original packaging and in the same condition as originally purchased.


Website: www.adooq.com
Order: [email protected]
Phone:
(866)930-6790 (US & Canada)
+1-323-389-9269 (Outside of US & CAN)
Fax:
(866)333-9607 (US & Canada)
+1-323-606-8156 (Outside of US & CAN)
Support:
[email protected]

High Purity Kinase Inhibitors on Signaling Pathways

Copyright© 2006-2017 Adooq BioScience LLC, All Rights Reserved.
4000 Barranca Parkway, Suite 250, Irvine, CA 92604 USA. Tel: 855-930-6790