NU6027Catalog No. A14136

Quick Overview

NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner.
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NU6027

Product Information
Catalog Num A14136
M. Wt 251.28
Formula C11H17N5O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 220036-08-8
Synonyms NU-6027, NU 6027
Chemical Name 6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine
SMILES Code C1CCC(CC1)COC2=NC(=NC(=C2N=O)N)N

Biological activity
Introduction
NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner.
Targets
ATR CDK2 DNA-PK CDK1
0.4 μM(Ki)1.3 μM(Ki)2.2 μM(Ki)2.5 μM(Ki)
Solubility
Solubility (25C)* In vitro DMSO 50 mg/mL (198.98 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (11.93 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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