IM-12Catalog No. A14196

Quick Overview

IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β (GSK-3β) inhibitor, activating downstream components of canonical Wnt signaling.
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IM-12

Product Information
Catalog Num A14196
M. Wt 377.41
Formula C22H20FN3O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1129669-05-1
Synonyms IM12, IM 12
Chemical Name 3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
SMILES Code CC1=C(C2=CC=CC=C2N1)C3=C(C(=O)N(C3=O)C)NCCC4=CC=C(C=C4)F

Biological activity
Introduction
IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β (GSK-3β) inhibitor, activating downstream components of canonical Wnt signaling.
Targets
GSK-3β
53 nM
Solubility
Solubility (25C)* In vitro DMSO 75 mg/mL (198.72 mM)
Water <1 mg/mL (<1 mM)
Ethanol 10 mg/mL heating (26.49 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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