MK-8245 TrifluoroacetateCatalog No. A15170

Quick Overview

MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy.
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MK-8245 Trifluoroacetate

Product Information
Catalog Num A15170
M. Wt 581.27
Formula C19H17BrF4N6O6
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1415559-41-9
Synonyms MK 8245 Trifluoroacetate, MK8245 Trifluoroacetate
Chemical Name 2-[5-[3-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acid; 2,2,2-trifluoroacetic acid
SMILES Code C1CN(CCC1OC2=C(C=CC(=C2)F)Br)C3=NOC(=C3)C4=NN(N=N4)CC(=O)O.C(=O)(C(F)(F)F)O

Biological activity
Introduction
MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy.
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