NVP-BGJ398 phosphateCatalog No. A15194

Quick Overview

NVP-BGJ398 phosphate is a novel selective, pan-specific FGFR inhibitor with IC50 of 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively; >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes.
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NVP-BGJ398 phosphate

Product Information
Catalog Num A15194
M. Wt 658.47
Formula C26H34Cl2N7O7P
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1310746-10-1
Synonyms BGJ-398 phosphate, BGJ 398 phosphate, NVP BGJ398 phosphate
Chemical Name 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea phosphate
SMILES Code CCN1CCN(CC1)C2=CC=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl.OP(=O)(O)O

Biological activity
Introduction
NVP-BGJ398 phosphate is a novel selective, pan-specific FGFR inhibitor with IC50 of 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively; >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes.
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High Purity Kinase Inhibitors on Signaling Pathways

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