D-69491Catalog No. A15457

Quick Overview

D-69491 (SU11464) is a small-molecule HER2 inhibitor, which was under development for the treatment of tumours with high expression of HER2, such as breast, ovarian, lung and pancreatic carcinomas.
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D-69491

Product Information
Catalog Num A15457
M. Wt 562.42
Formula C25H26Cl2FN7O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 346599-65-3
Synonyms D69491, SU 11464, SU11464, D 69491
Chemical Name 5-[(Z)-[4-(3-chloro-4-fluoroanilino)-6-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-ylidene]methyl]-4-methyl-N-(2-morpholin-4-ylethyl)-1H-pyrrole-2-carboxamide;hydrochloride
SMILES Code CC1=C(NC(=C1)C(=O)NCCN2CCOCC2)C=C3C4=C(NC3=O)N=CN=C4NC5=CC(=C(C=C5)F)Cl.Cl

Biological activity
Introduction
D-69491 (SU11464) is a small-molecule HER2 inhibitor, which was under development for the treatment of tumours with high expression of HER2, such as breast, ovarian, lung and pancreatic carcinomas.
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