AfuresertibCatalog No. A16392

Quick Overview

Afuresertib is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.
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Afuresertib

Product Information
Catalog Num A16392
M. Wt 427.32
Formula C18H17Cl2FN4OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1047644-62-1
Synonyms GSK 2110183, GSK2110183, GSK-2110183
Chemical Name N-[(2S)-1-amino-3-(3-fluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)thiophene-2-carboxamide
SMILES Code CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=CC=C3)F)CN)Cl

Biological activity
Introduction
Afuresertib is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.
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High Purity Kinase Inhibitors on Signaling Pathways

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