ATM / ATR



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Catalog No. Product Name Application Product Information
A10133 SALE

BEZ235 (NVP-BEZ235, Dactolisib)

PI3K/mTOR Inhibitor
BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes.
A15794 SALE

AZD6738

ATR inhibitor
AZD6738 is a potent inhibitor of ATR kinase activity with an IC50 of 1 nM against the isolated enzyme and 74 nM against ATR kinase-dependent CHK1 phosphorylation in cells.
A13289 SALE

VE-822

ATR inhibitor
VE-822 is an potent ATR inhibitor.
A13328

ETP-46464

ATR inhibitor
ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM.
A13205

AZ-20

ATR kinase inhibitor
AZ20 is a potent and selective inhibitor of ATR with an IC50 value of 5 nM.
A13191 SALE

CGK 733

ATM/ATR inhibitor
CGK733 is a selective inhibitor of ATR and ATM kinases. Induces cell death in prematurely senescent breast cancer cells.
A11586

Torin 2

mTOR inhibitor
Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively).
A11991

Schisandrin B

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Schisandrin B is the most abundant dibenzocyclooctadiene isolated from the fruit of Schisandra chinensis (Turcz) Baillon or Wu-Wei-Zi (transliterally meaning "the fruit of five tastes" in Chinese), which is a commonly used tonic herb in Chinese medicine, particularly for the treatment of liver ailments.
A11605 SALE

VE-821

ATM/ATR inhibitor
VE-821 is a potent and selective inhibitor of protein kinase ATR.
A10507 SALE

KU-60019

ATM Inhibitor
KU-60019 is a potent and specific ATM inhibitor with IC50 of 6.3 nM.
A11161 SALE

Wortmannin

PI3K inhibitor

Wortmannin is a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC50 = 2 - 4 nM) which also potently inhibits polo-like kinase 1 (PLK1) (IC50 = 5.8 nM).

A11086

CP-466722

ATM inhibitor
CP-466722 is a specific ATM inhibitor that inhibits cellular ATM-dependent phosphorylation events and disruption of ATM function resulted in characteristic cell cycle checkpoint defects.
A10506 SALE

KU-55933

ATM inhibitor
KU-55933 is an ATM inhibitor by suppressing cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt.
A15842 SALE

Mirin

ATM Inhibitor
Mirin prevents ATM activation in response to double strand breaks (IC50 = 12 uM) and induces G2 cell cycle arrest.
A14136

NU6027

ATR/CDK inhibito
NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner.

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