Catalog No.
Product Name
Application
Product Information
Product Citation
- Apaziquone is an indolequinone bioreductive prodrug and analog of mitomycin C with potential antineoplastic and radiosensitization activities.
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Topoisomerase inhibitor
Epirubicin is a cell-permeable antitumor antibiotic. A stereoisomer of Doxorubicin that exhibits reduced cardiotoxicity. Epirubicin?€?s antitumor actions are mediated by targeting and inhibiting Topo II (topoisomerase II).- Xiu-wu Pan, .et al. , Oncol Rep, 2016, Jan;35(1):334-42 PMID: 26496799
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Topoisomerase I inhibitor
9-Aminocamptothecin is a topoisomerase I inhibitor with potent anticancer activity. -
HDAC inhibitor
Resminostat, also known as RAS2410, is a potent inhibitor of histone deacetylase (HDAC) classes I and II. It binds to and inhibits HDACs leading to an accumulation of highly acetylated histones. -
topoisomerase II inhibitor
Ametantrone (AM) is a synthetic 9,10-anthracenedione bearing two (hydroxyethylamino)ethylamino residues at positions 1 and 4 along with other anthraquinones and anthracyclines. -
HDAC4 inhibitor
Tasquinimod is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling. - Fosteabine is an oral and prodrug analogue of cytarabine which is resistant to deoxycytidine deaminase.
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PARP inhibitor
PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM).- Wigle TJ, .et al. , SLAS Discov, 2019, Dec 19:2472555219883623 PMID: 31855104
- Alvin Z.Lu, .et al. , Biochem Pharmacol, 2019, May 7. pii: S0006-2952(19)30171-6 PMID: 31075269
- Palifosfamide is a synthetic mustard compound with potential antineoplastic activity.
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DNA-PK inhibitor
NU7026 is a novel DNA-dependent protein kinase inhibitor that potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia.- Velichko AK, .et al. , Nucleic Acids Res, 2019, May 22. pii: gkz436 PMID: 31114877
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HDAC6 inhibitor
ACY-241 is a new, selective and orally available inhibitor of HDAC6.- Bae J, .et al. , Leukemia, 2018, Sep;32(9):1932-1947 PMID: 29487385
- Bleomycin hydrochloride is an antitumor antibiotic which induces apoptosis.
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natural cyclic oligopeptide antibiotic
Antibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression. -
eIF4A3 inhibitor
eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM). -
Topoisomerase II inhibitor
Pixantrone is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity. -
DNA topoisomerase II inhibitor
Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase.- Xiaoling Li, .et al. , ACS Appl. Bio Mater, 2020, 3, 3, 1769-1778
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HDAC inhibitor
RG2833 ( is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3. -
modified nucleoside
6-O-Methyl Guanosine is a modified nucleoside. 6-O-Methyl Guanosine (6-methylguanosine) inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line. - N2-methylguanosine is a modified nucleoside that occurs at several specific locations in many tRNA's.
- Trifloxystrobin (CGA 279202) is a fungicide, with EC50s of 23.0 μg/L and 1.7 μg/L for Daphnia magna neonate and embryos, respectively, after treatment for 48 h.
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topoisomerase 1 inhibitor
Genz-644282 is a non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity. -
HDAC3 inhibitor
RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC.- Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138
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DNA-PK inhibitor
KU0060648 is a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK), (IC50 = 8.6 nM); with 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases. KU-0060648 enhances HDR efficiency and attenuates NHEJ frequency. - Actinomycin D is a metabolite isolated from Streptomyces parvulus that binds to the GpC steps of DNA. The compound acts as an antibiotic and is more effective against gram-positive bacteria than gram negative bacteria.
- Zegui N, .et al. , Cancer Research, 2022, FEBRUARY 22 PMID: 35502544
- Lina Gu, .et al. , Molecular Cancer, 2022, 21:217
- Chauhan D, .et al. , Cell Rep, 2018, Nov 27;25(9):2354-2368.e5 PMID: 30485805
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Thymidylate synthase inhibitor
Nolatrexed Dihydrochloride is an antifolate thymidylate synthase inhibitor. -
1,3-β-D-glucan synthase inhibitor
Caspofungin is an antifungal medicine. It is used to help the body overcome serious fungus infections, including Candida and Aspergillosis infections. It is also used to treat serious fungus infections when other medicines (e.g., amphotericin B, itraconazole) have failed. -
1,3-β-D-glucan synthase inhibitor
Micafungin (Mycamine; FK463) is an echinocandin antifungal drug which can inhibit 1,3-beta-D-glucan synthase.- Kate Chatfield-Reed, .et al. , Genetics, 2016, Apr; 202(4): 1365-1375 PMID: 26896331
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NNRT inhibitor
Delavirdine is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). -
biomarker
N6-Etheno 2'-deoxyadenosine is a reactive oxygen species (ROS)/reactive nitrogen species (RNS)-induced DNA oxidation product, used as a biomarker to evaluate chronic inflammation and lipid peroxidation in animal or human tissues. - Tubercidin is an adenosine analog, is an antibiotic obtained from Streptomyces tubercidicus.
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human topoisomerase I (Top1) inhibitor
Top1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM. - Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.
