DNA Damage

Items 201-250 of 613

per page
Set Descending Direction
Catalog No.
Product Name
Application
Product Information
Product Citation
  1. SMN2 splicing modifier

    RG7800 a small molecule SMN2 splicing modifier to enter human clinical trials to treat spinal muscular atrophy.
  2. ATR inhibitor

    ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM.
  3. 3-Methylcytidine, a urinary nucleoside, can be used as a biomarker of four different types of cancer: lung cancer, gastric cancer, colon cancer, and breast cancer.
  4. JAK2/HDAC dual inhibitor

    JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines.
  5. IRE-1α inhibitor

    6-Bromo-2-hydroxy-3-methoxybenzaldehyde (NSC95682) is an IRE-1α inhibitor with an IC50 of 0.08 μM, extracted from patent WO 2008154484 A1, IRE-lα inhibitor compound 3-5.
  6. glucan synthase inhibitor

    Anidulafungin is a semi-synthetic cyclic lipopeptide belonging to the echinocandin class that was reported in 1995 and commercially developed by Eli Lilly. Anidulafungin inhibits the synthesis of ??-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi and is extensively referenced in the literature with over 400 citations.
  7. Topo II inhibitor

    BNS-22 is a potent small molecule inhibitor of Topo II (IC50 2.8 M and 0.42 M for Topo II alpha and Topo II beta, respectively).
  8. HDACs/mTOR Inhibitor 1

    HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies.
  9. Uramustine is a chemotherapy drug which belongs to the class of alkylating agents.
  10. Squalene synthase inhibitor

    YM-53601 is a novel squalene synthase inhibitor. It suppresses lipogenic biosynthesis and lipid secretion in rodents.
  11. Beaucage reagent is found to be potent in causing DNA cleavage.
  12. cell cycle inhibitor

    Briciclib disodium salt is a benzyl styryl sulfone analog, and a disodium phosphate ester prodrug of ON 013100, with potential antineoplastic activity.
  13. IMPDH inhibitor

    AVN-944 (also known as VX-944) serves as an effective oral inhibitor, specifically targeting and inhibiting IMPDH (inosine monophosphate dehydrogenase). This enzyme plays a crucial role as a rate-limiting factor in the synthesis of guanine nucleotides from scratch. Additionally, AVN-944 acts against the synthesis of RNA in arenaviruses, effectively preventing arenavirus infections. Demonstrating a wide spectrum of anti-cancer properties, AVN-944 is utilized in research related to multiple myeloma (MM) and acute myeloid leukemia (AML).

  14. 3'-Azido-3'-deoxy-beta-L-uridine (Compound 25) is a nucleoside derivative.
  15. Topoisomerase I inhibitor

    CKD-602 is a topoisomerase I inhibitor.
  16. TNKS1/2 inhibitor

    JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2).
  17. DNA topoisomerase II inhibitor

    Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor.
  18. N6,N6-Dimethyladenosine is a modified ribonucleoside previously found in rRNA, and also exhibits in mycobacterium bovis Bacille Calmette-Gu??rin tRNA.
  19. IRE1 Rnase inhibitor

    4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.
  20. PERK inhibitor

    ISRIB (trans-isomer) is a potent and selective small molecule inhibitor of PERK signaling (IC50 ~5 nM) that can potently reverse the effects of eIF2α phosphorylation.
  21. IRE1α inhibitor

    APY29 inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.
  22. Topoisomerase II inhibitor

    NK314 is a novel synthetic benzo[c]phenanthridine alkaloid that shows strong antitumor activity. It inhibited topoisomerase II activity and stabilized topoisomerase II-DNA cleavable complexes.
  23. Triacsin C, originally isolated from Streptomyces sp., is an inhibitor of long fatty acid acyl-CoA synthetase (IC50 = 6.3 uM in Raji cells).
  24. HDAC6 inhibitor

    Nexturastat A is an aryl urea derivative that acts as a potent and highly selective inhibitor of histone deacetylase 6 (HDAC6) (IC50= 5.02 +/- 0.60 nM).
  25. HDAC inhibitor

    TMP 269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.
  26. ATR/CDK inhibitor

    NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner.
  27. topoisomerase I/II inhibitor

    TAS 103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models
  28. Topoisomerase II inhibitor

    Voreloxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication
  29. PARP-1 inhibitor

    Rucaparib is a potent inhibitor of purified full-length human PARP-1 and shows higher inhibition of cellular PARP in LoVo and SW620 cells.
  30. SIRT1 activator

    SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.
  31. HDAC6 inhibitor

    HPOB is a potent inhibitor of histone deacetylase 6 (HDAC6; IC50 = 56 nM).
  32. eIF4E/eIF4G inhibitor

    4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 uM.
  33. Blasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes, and acts as a DNA and protein synthesis inhibitor.
  34. NAD(+)-dependent histone deacetylase Sir2p inhibitor

    Splitomicin is a selective NAD(+)-dependent histone deacetylase Sir2p inhibitor with IC50 of 60 uM, showing a higher activity in a cell-based assay.
  35. SIRT2 inhibitor

    AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM.
  36. isoleucyl t-RNA synthetase inhibitor

    Mupirocin is an isoleucyl t-RNA synthetase inhibitor.
  37. HDAC inhibitor

    Santacruzamate A (CAY10683) is a potent and selective HDAC inhibitor with IC50 of 119 pM for HDAC2, >3600-fold selectivity over other HDACs.
  38. DNA/RNA Synthesis inhibitor

    Chlorambucil is a nitrogen mustard alkylating agent.
  39. protein synthesis inhibitor

    Puromycin 2HCl is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.
  40. Tankyrase inhibitor

    WIKI4 is a novel Tankyrase inhibitor with IC50 of 15 nM for TNKS2.
  41. MTH1 (NUDT1) inhibitor

    (S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM.
  42. eIF4F subunit interaction inhibitor

    4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction.
  43. PERK inhibitor

    ISRIB is a potent and selective PERK inhibitor with IC50 of 5 nM.
  44. APE1 inhibitor

    CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM.
  45. PARP3 inhibitor

    ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.
  46. HDAC inhibitor

    TMP195 is the most potent and selective class IIa HDAC inhibitor.
  47. RNA polymerase inhibitor

    BMH-21 is a potent small molecule DNA intercalator. BMH-21 binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription.
  48. HDAC4/5 inhibitor

    LMK-235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor.
  49. HDAC inhibitor

    4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity.

Items 201-250 of 613

per page
Set Descending Direction