DUB

Inhibitory Selectivity
Catalog No.Inhibitor Name DUBUSP/UBPUCHOther
A13190PR-619
**
***
JOSD2,SENP6 core,DEN1
A13277P5091
**
A12715LDN-57444
****
A13209IU1
*
A12933P22077
*
A14030ML323
****
A15391b-AP15
***
A10988Degrasyn
Bcr-Abl

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A10988

WP1130 ( Degrasyn )

DUB/Bcr/ABL Inhibitor
WP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells.
A12830

DUBs-IN-3

USP7/USP8 inhibitor
DUBs-IN-3 is a potent deubiquitinase enzyme inhibitor with IC50s of 3.1 uM for USP8; >30 fold selectivity over USP7 (IC50 > 100 uM).
A12827

DUBs-IN-1

USP7/USP8 inhibitor
DUBs-IN-1 is a potent deubiquitinase enzyme inhibitor with IC50s of 18 uM/0.71 uM for USP7/USP8 respectively.
A12822

SJB3-019A

USP1 inhibitor
SJB3-019A is a potent and novel usp1 inhibitor. SJB3-019A (IC50 = 0.0781 uM) was 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells.
A12813

USP7-IN-1

USP7 inhibitor
USP7-IN-1 is a novel selective and reversible inhibitor of USP7 with IC50 of 33 uM; less or no inhibition on USP5, USP8, Uch-L1, Uch-L3 and Caspase(IC50>200 uM); HCT116 cell viability GI50 is 67 uM.
A15391 SALE

b-AP15 (NSC 687852)

DUB inhibitor
NSC 687852 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs.
A15321

Vialinin A

USP4 Inhibitor
Vialinin A is a terphenyl compound originally isolated from the fungi T. terrestris and T. vialis.
A15238

SJB2-043

USP1 Inhibitor
SJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor.
A14030 SALE

ML-323

USP1-UAF1 inhibitor
ML323 is a selective and highly potent USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.
A13352

HBX 41108

USP 7 inhibitor
HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM).
A13209

IU1

Usp14 inhibitor
IU1 is a selective inhibitor of Usp14. It inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 uM).
A13277

P005091

DUB/USP7 Inhibitor
P005091 is a selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 uM).
A12715 SALE

LDN-57444

UCH-L1 Inhibitor
LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1.
A12933

P 22077

USP7 inhibitor
P 22077 is a cell-permeable inhibitor of the ubiquitin-specific protease (IC?? = 8.6 μM) and the closely related deubiquitinase (DUB) USP47.
A13190 SALE

PR-619

DUB inhibitor
PR-619 is a cell-permeable, reversible, and broad-spectrum inhibitor of the deubiquitinylating enzymes (DUBs).
A12842

DUBs-IN-2

USP7/USP8 inhibitor
DUBs-IN-2 is a potent deubiquitinase enzyme inhibitor with IC50s of 7.2 uM/0.93 uM for USP7/USP8 respectively.

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