DUB



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Catalog No. Product Name Application Product Information
A12827

DUBs-IN-1

USP7/USP8 inhibitor
DUBs-IN-1 is a potent deubiquitinase enzyme inhibitor with IC50s of 18 uM/0.71 uM for USP7/USP8 respectively.
A12842

DUBs-IN-2

USP7/USP8 inhibitor
DUBs-IN-2 is a potent deubiquitinase enzyme inhibitor with IC50s of 7.2 uM/0.93 uM for USP7/USP8 respectively.
A12830

DUBs-IN-3

USP7/USP8 inhibitor
DUBs-IN-3 is a potent deubiquitinase enzyme inhibitor with IC50s of 3.1 uM for USP8; >30 fold selectivity over USP7 (IC50 > 100 uM).
A13352

HBX 41108

USP 7 inhibitor
HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM).
A13209

IU1

Usp14 inhibitor
IU1 is a selective inhibitor of Usp14. It inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 uM).
A12715 SALE

LDN-57444

UCH-L1 Inhibitor
LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1.
A14030 SALE

ML-323

USP1-UAF1 inhibitor
ML323 is a selective and highly potent USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.
A15391 SALE

NSC 687852

DUB inhibitor
NSC 687852 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs.
A12933

P 22077

USP7 inhibitor
P 22077 is a cell-permeable inhibitor of the ubiquitin-specific protease (IC?? = 8.6 μM) and the closely related deubiquitinase (DUB) USP47.
A13277

P005091

DUB/USP7 Inhibitor
P005091 is a selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 uM).
A13190 SALE

PR-619

DUB inhibitor
PR-619 is a cell-permeable, reversible, and broad-spectrum inhibitor of the deubiquitinylating enzymes (DUBs).
A15238

SJB2-043

USP1 Inhibitor
SJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor.
A12822

SJB3-019A

USP1 inhibitor
SJB3-019A is a potent and novel usp1 inhibitor. SJB3-019A (IC50 = 0.0781 uM) was 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells.
A12813

USP7-IN-1

USP7 inhibitor
USP7-IN-1 is a novel selective and reversible inhibitor of USP7 with IC50 of 33 uM; less or no inhibition on USP5, USP8, Uch-L1, Uch-L3 and Caspase(IC50>200 uM); HCT116 cell viability GI50 is 67 uM.
A15321

Vialinin A

USP4 Inhibitor
Vialinin A is a terphenyl compound originally isolated from the fungi T. terrestris and T. vialis.
A10988

WP1130 ( Degrasyn )

DUB/Bcr/ABL Inhibitor
WP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells.

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