ERK

Inhibitory Selectivity
Catalog No.Inhibitor Name ERK1ERK2ERK5ERKOther
A12824SCH772984
***
****
A12505VX-11e
***
GSK3,AURA,CDK2
A15802DEL-22379
*
*
A11794Ulixertinib
****
A13420GDC-0994
***
****
A14119FR 180204
*
**
A11609XMD8-92
**
A16232ERK5-IN-1
**
A11225Pluripotin (SC-1)
**
RasGAP

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A11225

Pluripotin (SC-1)

ERK1/RasGAP Inhibitor
The activity of Pluripotin (SC-1) is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.
A16232

ERK5-IN-1

ERK5 inhibitor
ERK5-IN-1 exhibits potent inhibition of ERK5 with cellular EC50 values of 0.19 uM and enzymatic IC50 values of 0.087 uM and of LRRK2[G2019S] with enzymatic IC50 values of 0.026uM.
A16231

APS-2-79

KSR/Ras inhibitor
APS-2-79 is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site.
A15802 SALE

DEL-22379

ERK inhibitor
DEL-22379 is a potent and selective ERK Dimerization inhibitor that inhibits ERK Dimerization without affecting ERK phosphorylation, forestalls tumorigenesis driven by RAS-ERK pathway oncogenes.
A13977

TMCB

CK2/ERK8 inhibitor
MCB has been shown to inhibit both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8/MAPK15) (IC50 = 0.50 uM for both CK2 and ERK8).
A11609 SALE

XMD8-92

BMK1/ERK5 inhibitor
XMD8-92 is a potent and selective BMK1/ERK5 inhibitor .
A14119 SALE

FR 180204

ERK inhibitor
FR 180204 is a novel and selective inhibitor of extracellular signal-regulated kinase (ERK), which may be a potential new therapy for rheumatoid arthritis.
A14090

XMD 17-109

ERK5 inhibitor
XMD17-109 is a novel, specific inhibitor of ERK-5 with an EC50 value of 4.2 uM in HEK293 cells.
A13420 SALE

GDC0994

ERK1/2 inhibitor
GDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways.
A12505 SALE

TCS ERK 11e (VX-11e)

ERK2 inhibitor
TCS ERK 11e (VX-11e) is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM).
A12824 SALE

SCH772984

ERK Inhibitor
SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.
A11794 SALE

Ulixertinib (BVD-523, VRT752271)

ERK1/ERK2 inhibitor
VRT752271 is a pyrrole inhibitors of ERK protein kinase.
A16233

Tomatidine

ERK/Akt/NF-kB inhibitor
Tomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-kB. possess anti-inflammatory properties.

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