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GPR



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Catalog No. Product Name Application Product Information
A11946

OC 000459

CRTH2 antagonist
OC 000459 is a potent, oral and selective CRTH2 (also known as DP2) antagonist.
A16184

NCRW0005-F05

GPR139 antagonist
NCRW0005-F05, first antagonist selective for GPR139 (IC50 value 0.21 uM); a useful tool to study GPR139 pharmacology, especially in combination with the GPR139 agonist JNJ 63533054.
A12994

TUG-770

FFA1/GPR40 Agonist
TUG-770 is a Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes.
A16069

Versipelostatin

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Versipelostatin is a novel GRP78/Bip molecular chaperone down-regulator of microbial origin that was isolated from the metabolite of Streptomyces versipellis strain 4083-SVS6.
A14542 SALE

GSK137647A

FFA4/GPR120 agonist
GSK137647A is a selective FFA4 agonist, with pEC50 of 6.3, 6.2, and 6.1 for human, Mouse and Rat FFA4, respectively.
A15452

APD597 (JNJ-38431055)

GPR119 agonist
APD597 is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119.
A15775

NIBR189

EBI2 (GPR183) receptor antagonist
NIBR189 is a small molecule antagonist of the Epstein-Barr virus-induced gene 2 (EBI2; GPR183) receptor with IC50 of 16 nM(Binding) and 11 nM (Functional).
A15507

6-OAU

GPR84 agonist
6-OAU is a surrogate agonist of GPR84; activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay.
A15095

GPR120 modulator 2

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GPR120 modulator 2 is useful for modulating G protein-coupled receptor 120 (GPR120).
A15094

GPR120 modulator 1

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GPR120 modulator 1 is useful for modulating G protein-coupled receptor 120 (GPR120).
A14952

Deoxycholic acid

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Deoxycholic acid, extracted from Pig bile, Suitability:Ethanol,ether,three oxygen methane,acetone,acetic acid,alkali hydroxide and alkali carbonate solution.
A13468

AMG 837

GPR40/FFA1 agonist
AMG-837 is a potent, orally bioavailable GPR40 agonist.
A14342 SALE

APD668

GPR119 agonist
APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively.
A13186 SALE

AZD1981

CRTH2 receptor antagonist
AZD1981, as a potent antagonist in a disease relevant cell system, inhibits DK-PGD2-induced CD11b expression in human eosinophils with IC50 of 10 nM.
A13716

AR-231453

GPR119 agonist
AR-231453 is a potent and selective small molecule agonis of GPR119 that enhances glucose dependent insulin secretion and glucagon like peptide-1 (GLP-1) release.
A12634

MBX-2982

GPR119 agonist
MBX-2982 is a potential first-in-class treatment for type 2 diabetes that targets G protein-coupled receptor 119 (GPR119), a receptor that interacts with bioactive lipids known to stimulate glucose-dependent insulin secretion.
A13359

Diphenyleneiodonium chloride

GPR3 agonist/NOS/ NADPH oxidases inhibitor
Diphenyleneiodonium chloride has been shown to be a potent irreversible inhibitor of NOS2 (iNOS) from macrophages and NOS3 (eNOS) from endothelial cells.
A16364

TC-G-1008

GPR39 agonist
TC-G-1008 is a GPR39 (zinc receptor) agonist (EC50 values are 0.4 and 0.8 nM for rat and human receptors respectively).

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