GSK-3 / Wnt / Hedgehog

Category
  1. γ-Secretase (28)
  2. Hedgehog (10)
  3. Wnt (17)
  4. β-catenin (3)
  5. GSK-3 (18)
  6. Smoothened (5)
Actions
  1. Activator (2)
  2. Agonist (1)
  3. Antagonist (6)
  4. Inhibitor (62)
  5. Modulator (7)


Items 1 to 25 of 79 total

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Catalog No. Product Name Application Product Information
A13728

AR-A 014418

GSK-3 inhibitor
AR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.
A12819

AZD1080

GSK3 inhibitor
AZD1080 is a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans.
A13060

AZD2858

GSK-3β inhibitor
AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats.
A11258

Begacestat (GSI-953)

γ-secretase inhibitor
Begacestat is a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
A15555

BIO-acetoxime

GSK-3 inhibitor
N/A
A15851

BML-284 (Wnt agonist 1)

Wnt agonist 1
Wnt agonist 1 is a cell-permeable Wnt signaling activator. It nduces beta-catenin and TCF-dependent transcriptional activity with EC50 value of 0.7 uM.
A12444

BMS 299897

γ-secretase inhibitor
BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo.
A11337

BMS 433796

γ-Secretase Inhibitor
BMS 433796 is a γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's disease.
A10157

BMS-708163

Gamma-secretase inhibitor
BMS-708163 is an oral gamma secretase inhibitor designed for selective inhibition of amyloid beta synthesis.
A13204

BMS-833923 (XL-139)

Smoothened inhibitor
BMS-833923 (or XL-139) is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity.
A16216

CCT251545

Wnt inhibitor
CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM.
A16214

CHF5074

γ-Secretase inhibitor
CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 uM, respectively.
A11085

CHIR-98014

GSK-3 inhibitor
CHIR-98014 is a very potent, selective, cell-permeable reversible inhibitor of GSK-3.
A10199

CHIR-99021

GSK-3 Inhibitor
CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.
A15296

Compound W

Gamma-secretase modulator
Compound W is a γ-secretase inhibitor that has been shown to lower the levels of secreted Aβ42 and Nβ25.
A16230

CP21R7

GSK-3β inhibitor
CP21R7 is a potent and selective GSK-3β inhibitor.
A10249

Cyclopamine

Hedgehog signaling inhibitor
Cyclopamine is a Smo or hedgehog signaling pathway inhibitor.
A10288

DAPT (GSI-IX)

Gamma secretase inhibitor
DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.
A11393

E 2012

gamma-secretase modulator
E 2012 is γ-secretase inhibitor.
A15840

ETC-159

Wnt inhibitor
ETC-159 is a potent and specific inhibitor of Wnt secretion. ETC-159 inhibits ??-catenin reporter activity in a dose-dependent manner with an IC50 of 2.9 nM.
A13795

FH535

β-Catenin/Tcf Inhibitor
A13815

FLI-06

Gamma-secretase inhibitor
FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A.
A13662

Flurbiprofen Axetil

gamma-secretase inhibitor
Flurbiprofen Axetil is potentnon-steroidal anti-inflammatory drug(NSAID).
A12433

Flurizan

gamma-secretase modulator
Flurizan is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity.
A11425

gamma-secretase modulator 1

Gamma-secretase modulator
gamma-secretase modulator 1 is a gamma-secretase modulator, gamma-secretase modulator 1 is useful for Alzheimer's disease.

Items 1 to 25 of 79 total

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