Histone demethylases



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Catalog No. Product Name Application Product Information
A16372

2,4-Pyridinedicarboxylic Acid

KDM inhibitor
2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is an inhibitor of histone lysine-specific demethylases that targets on JMJD2A (KDM4A), KDM4C, KDM4E (IC50, 1.4 uM), KDM5B (IC50, 3 uM), KDM6A and other 2-oxogynases.
A16371

AS8351

Histone demethylase inhibitor.
AS8351 is a histone demethylase inhibitor.
A12734

CBB1003

LSD1 inhibitor
CBB1003 is a novel histone demethylase LSD1 inhibitor with IC50 of 10.54 uM.
A16177

CPI 4203

KDM5 demethylases inhibitor
CPI 4203 is a selective inhibitor of KDM5 demethylases, structurally related to CPI 455 but ~25-fold less potent (IC50 value 250 nM for inhibition of full length KDM5A).
A16178

CPI 455

KDM5 inhibitor
CPI 455 possesses the target specificity required for an in vitro tool compound for exploring KDM5-dependent disease biology, including drug tolerance.
A12918 SALE

GSK J1

Histone demethylase inhibitor
GSK J1 is a potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX
A12732 SALE

GSK-J4

Demethylase Inhibitor
GSK J4 is a cell permeable prodrug rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor; attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 uM for the inhibition of TNF?? release).
A14277

IOX1

2OG oxygenases Inhibitor
IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases.
A13806 SALE

JIB-04

Histone Demethylase inhibitor
JIB-04 is a pan-selective Jumonji histone demethylase inhibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively.
A15829

ML-324

JMJD2 inhibitor‎
ML-324 is a potent JMJD2 demethylase inhibitor with demonstrated antiviral activity.
A13246

OG-L002

LSD1 inhibitor
OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively.
A16373

TC-E 5002

KDM2/7 inhibitor
TC-E 5002, selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 uM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). Inhibits growth of HeLa and KYSE-150 cancer cells in vitro.
A13358 SALE

Tranylcypromine hydrochloride

LSD1/BHC110 & MAO inhibitor
Tranylcypromine hydrochloride is a non-selective MAO-A/B inhibitor.

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