Histone Methyltransferase



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Catalog No. Product Name Application Product Information
A13947

3-deazaneplanocin A HCl

Histone Methyltransferase inhibitor
3-deazaneplanocin A, also known as DZNep, is a well-known histone methyltransferase inhibitor, which disrupts polycomb-repressive complex 2 (PRC2), and induces apoptosis, while inhibiting proliferation and metastasis, in cancer cells, including acute myeloid leukemia, breast cancer and glioblastoma.
A15969 SALE

A-366

lysine methyltransferase G9a inhibitor
A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor with IC50 value of 3.3 nM.
A15916

AMI-1

PRMTs Inhibitor
AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 uM and 8.8 uM for yeast Hmt1p and human PRMT1, respectively.
A16405

Amodiaquine dihydrochloride dihydrate

-
Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase in human erythrocytes, also used as an antimalarial and anti-inflammatory agent.
A13061

AZ505

SMYD2 inhibitor
AZ505 is a potent and highly selective inhibitor of the oncogenic protein SMYD2(IC50=0.12 uM) with potential anticancer activity, >600 fold than SMYD3(IC50>83.3 uM); DOT1L(IC50>83.3 uM);EZH2(IC50>83.3 uM).
A13169

AZ505 ditrifluoroacetate

SMYD2 inhibitor
AZ505 ditrifluoroacetate is a potent and highly selective inhibitor of the oncogenic protein SMYD2(IC50=0.12 uM) with potential anticancer activity, >600 fold than SMYD3(IC50>83.3 uM); DOT1L(IC50>83.3 uM);EZH2(IC50>83.3 uM).
A11763 SALE

BIX 01294

Histone Methyltransferase inhibitor
BIX 01294 is a G9a-like protein and G9a histone lysine methyltransferase inhibitor.
A14401

BRD4770

Histone Methyltransferase inhibitor
BRD4770 is a novel histone methyltransferase inhibitor.
A13876

C7280948

PRMT1 inhibitor
C7280948 is an inhibitor of histone arginine methyltransferase PRMT1 with IC50 values of 12.75 uM.
A12812

Chaetocin

HMT Inhibitor
Chaetocin is a histone methyltransferase SUV39H1 inhibitor (IC50 = 0.8 μM). Induces apoptosis in myeloma cell lines in vitro; exhibits antiproliferative activity in a mouse myeloma model in vivo.
A16357

CPI-1205

EZH2 inhibitor
CPI-1205 is a highly potent (biochemical IC50 = 0.002 ??M, cellular EC50 = 0.032 uM) and selective inhibitor of EZH2.
A15920 SALE

CPI-169

EZH2 inhibitor
CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.
A15908

CPI-360

EZH1 inhibitor
CPI-360 is a potent, selective,and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.
A11377

DZNep

EZH2 Inhibitor
3 Deazaneplanocin A (DZNep) is a cyclopentenyl analog of 3-deazaadenosine, originally synthesized as an inhibitor of S-adenosyl-L-homocysteine hydrolase.
A12711

EI1

EZH2 inhibitor
EI1 is a potent and selective small molecule inhibitor of EZH2 with IC50 values of 15 nM and 13 nM for wild type EZH2 and EZH2 Y641F mutant, respectively.
A12735 SALE

EPZ-5676 (Pinometostat)

DOT1L Inhibitor‎
EPZ-5676 is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity.
A12712 SALE

EPZ-6438 (Tazemetostat)

EZH2 inhibitor
EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. It induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.
A12983

EPZ004777

DOT1L inhibitor
EPZ004777 is a potent, selective inhibitor of DOT1L. EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes.
A12439

EPZ005687

EZH2 inhibitor
EPZ005687 is a potent inhibitor of EZH2 (K(i) of 24 nM)
A15544

EPZ011989

EZH2 Inhibitor
EPZ011989 is a potent, selective orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 wt and EZH2 Y646; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase.
A16377

EPZ020411

PRMT6 inhibitor
EPZ020411 is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has >10 fold selectivity for PRMT6 over PRMT1 and PRMT8.
A16375

EPZ031686

SMYD3/ MEKK2 inhibitor
EPZ031686 is a noncompetitive inhibitor for SMYD3 and MEKK2 with a Ki=1.2 and 1.1 nM respectively.
A11757 SALE

GSK126

EZH2 inhibitor
GSK126 is a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase activity, decreases global H3K27me3 levels and reactivates silenced PRC2 target genes.
A13114 SALE

GSK343

EZH2 inhibitor
GSK343 is a potent histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor (IC= 4 nM). Diplays 1000-fold selectivity for other HMTs except EZH1 (60-fold selectivity). GSK343 inhibits H3K27 methylation in HCC1806 cells with an IC of <200nM (measured by immunofluorescence).
A15549

GSK503

EZH2 Inhibitor
GSK-503 is a potent EZH2 inhibitor with potential anticancer activity.

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