IKK/IκB

Inhibitory Selectivity
Catalog No.Inhibitor Name IκBIKKOther
A11957BAY 11-7082
*
E2-conjugating enzymes
A12836IKK-16
***
A11579TPCA-1
****
A12559BMS-345541
**
A12746SC-514
**
CDK2/CyclinA,AUR2,PRAK
A12470Bay 11-7085
*
A12789PS-1145
***
A15488LY2409881
****
A11148BX-795
PDK-1,c-Kit,CDK2/CyclinE
A12837IMD 0354
A11323Bardoxolone Methyl
NF-κB,Nrf2
A15900AZD3264
A12953WS6
EBP1
A12952WS3
EBP1
A11318BMS-345541 HCl
**
A11339Bay 65-1942
*
A11485MRT67307
**
TBK1
A13108PHA 408
A15171MLN120B

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



Items 1 to 25 of 28 total

per page
Page:
  1. 1
  2. 2

Set Descending Direction
Catalog No. Product Name Application Product Information
A16297

Amlexanox

IKKε /TBK1 inhibitor
Amlexanox is an anti-inflammatory antiallergic immunomodulator used to treat recurrent aphthous ulcers (canker sores), and (in Japan) several inflammatory conditions.
A15900

AZD3264

IKK2 inhibitor‎
AZD3264 is a novel IKK2 inhibitor.
A11324

Bardoxolone (CDDO)

IκB/IKK inhibitor
Bardoxolone methyl, previously known as RTA 402, is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs).
A11323 SALE

Bardoxolone methyl (RTA 402)

IκB/IKK inhibitor
Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.
A12470

BAY 11-7085

-
BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM
A11957 SALE

Bay 11-7821

E2 ubiquitin conjugating enzyme inhibitor
Bay 11-7821 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation.
A11339

Bay 65-1942

IKKβ inhibitor
Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity.
A11338

Bay 65-1942 HCl

IKKβ kinase inhibitor
Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity.
A15018

Bay 65-1942 R form

IKK Inhibitor‎
Bay 65-1942 (R form) is an ATP-competitive inhibitor that selectively targets IKK?? kinase.
A12559

BMS-345541

-
BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM
A11318 SALE

BMS-345541 HCl

IKK inhibitor
BMS 345541 is a cell-permeable and highly selective IKB kinase (IKK) inhibitor that binds at allosteric site of the enzyme and blocks NF-kB-dependent transcription in mice.
A11148 SALE

BX-795

PDK-1 inhibitor
BX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis.
A16299

CDDO-EA

Nrf2 activator
CDDO-EA is an activator of Nrf2/ARE; Neuroprotective effect.
A16298

IKK epsilon-IN-1

IKK-ε inhibitor
IKK epsilon-IN-1 is a potent IKKε inhibitor; inhibit the in-situ IKK ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM.
A12836 SALE

IKK-16

IKK Inhibitor
IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
A11452

IKK-2 inhibitor VIII

IKK Inhibitor
IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM.
A11463

IKK-3 Inhibitor

IKK Inhibitor
IKK-3 Inhibitor is a potent, selective, inhibitor of IKK-epsilon kinase with IC50 of 40 nM; inactive at IKK-alpha and IKK-beta.
A12837 SALE

IMD 0354

IKK Inhibitor
IMD 0354 is an inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation.
A15488

LY2409881

IKK2 inhibitor
LY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases.
A15171

MLN120B

IκB Kinase β Inhibitor
MLN120B is a potent and effective IKKbeta inhibitor.
A11485

MRT67307

SIK/TBK-1/IKKe inhibitor
MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively.
A13108

PHA 408

IKK-2 inhibitor
PHA 408 is a potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50: 40 nM), which binds IKK-2 tightly with a relatively slow off rate; highly recommended tool to investigate the mechanisms by which IKK-2 regulates NF-KB signaling.
A12789 SALE

PS-1145

IKK inhibitor
PS-1145 is a highly specific IKB kinase (IKK) inhibitor that efficiently inhibits both basal and induced NF-kB activity in PC cells.
A12746 SALE

SC-514

IκB/IKK Inhibitor
SC-514 is an orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK.
A11579 SALE

TPCA-1

IKK-2 inhibitor
TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1.

Items 1 to 25 of 28 total

per page
Page:
  1. 1
  2. 2

Set Descending Direction