IKK

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  1. Inhibitor (20)


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Catalog No. Product Name Application Product Information
A15900

AZD3264

IKK2 inhibitor‎
AZD3264 is a novel IKK2 inhibitor.
A11324

Bardoxolone (CDDO)

IκB/IKK inhibitor
Bardoxolone methyl, previously known as RTA 402, is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs).
A11323

Bardoxolone methyl (RTA 402)

IκB/IKK inhibitor
Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.
A11339

Bay 65-1942

IKKβ inhibitor
Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity.
A11338

Bay 65-1942 HCl

IKKβ kinase inhibitor
Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity.
A15018

Bay 65-1942 R form

IKK Inhibitor‎
Bay 65-1942 (R form) is an ATP-competitive inhibitor that selectively targets IKK?? kinase.
A11318

BMS-345541 HCl

IKK inhibitor
BMS 345541 is a cell-permeable and highly selective IKB kinase (IKK) inhibitor that binds at allosteric site of the enzyme and blocks NF-kB-dependent transcription in mice.
A16298

IKK epsilon-IN-1

IKK-ε inhibitor
IKK epsilon-IN-1 is a potent IKKε inhibitor; inhibit the in-situ IKK ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM.
A12836

IKK-16

IKK Inhibitor
IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
A11452

IKK-2 inhibitor VIII

IKK Inhibitor
IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM.
A11463

IKK-3 Inhibitor

IKK Inhibitor
IKK-3 Inhibitor is a potent, selective, inhibitor of IKK-epsilon kinase with IC50 of 40 nM; inactive at IKK-alpha and IKK-beta.
A12837

IMD 0354

IKK Inhibitor
IMD 0354 is an inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation.
A10535

Lomustine (CeeNU)

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Lomustine is an alkylating nitrosourea compound that possesses antitumor activity similar to Carmustine causing DNA interstrand cross-linking.
A15488

LY2409881

IKK2 inhibitor
LY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases.
A15171

MLN120B

IκB Kinase β Inhibitor
MLN120B is a potent and effective IKKbeta inhibitor.
A11485

MRT67307

SIK/TBK-1/IKKe inhibitor
MRT67307 is a potent and dual IKK? and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively.
A13108

PHA 408

IKK-2 inhibitor
PHA 408 is a potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50: 40 nM), which binds IKK-2 tightly with a relatively slow off rate; highly recommended tool to investigate the mechanisms by which IKK-2 regulates NF-KB signaling.
A12789

PS-1145

IKK inhibitor
PS-1145 is a highly specific IKB kinase (IKK) inhibitor that efficiently inhibits both basal and induced NF-kB activity in PC cells.
A12746

SC-514

IκB/IKK Inhibitor
SC-514 is an orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK.
A11579

TPCA-1

IKK-2 inhibitor
TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1.
A14804

Wedelolactone

IKK Inhibitor II
Wedelolactone, a compound originally extracted from Eclipta alba, has been shown to inhibit caspase-11, which is a key regulator of proinflammatory cytokine IL-1?? maturation and pathological apoptosis.

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