Integrin

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Catalog No.
Product Name
Application
Product Information
Product Citation
  1. VCAM-1 antagonist

    CDP323 is a small-molecule prodrug antagonist of the vascular cell adhesion molecule 1 binding to ??4-integrins
  2. Integrin inhibitor

    Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.
  3. Integrin inhibitor

    Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.
  4. α4β1/α4β7 integrin antagonist

    Firategrast is an orally bioavailable alpha4 beta1/alpha4 beta7 integrin antagonist designed to reduce trafficking of lymphocytes into the central nervous system (CNS).
  5. Pyrintegrin is a cell-permeable small molecule that promotes human embryonic stem cell (hESC) survival by > 30-fold.
  6. Integrin Inhibitor

    A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC50 value of 20 nM and 25 nM, respectively.
  7. Integrin receptor antagonist

    GLPG0187 is a broad spectrum integrin receptor antagonist with antitumor activity; inhibits αvβ1-integrin with an IC50 of 1.3 nM.
  8. Integrin agonist

    Leukadherin 1 is an allosteric activator of CD11b/CD18. Increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50 = 4 μM).
  9. αvβ3 integrin inhibitor

    Cyclo (-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin.
  10. lpha-2-integrin inhibitor

    E7820 is a small molecule and aromatic sulfonamide derivative with potential antiangiogenic and antitumor activities. E7820 inhibits angiogenesis by suppressing integrin alpha 2, a cell adhesion molecule expressed on endothelial cells.
  11. Inhibits integrin binding to RGD motifs

    RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.
  12. Integrin inhibitor

    Cyclo(RGDyK) trifluoroacetate is a potent and selective alphaVbeta3 integrin inhibitor with IC50 of 20 nM.
  13. αV integrins inhibitor

    CWHM 12 can suppress all 5 alpha V integrins. CWHM12 not only worked the same way to prevent fibrosis as the genetic deletion method, it also prevent the progression of existing fibrosis in the liver and lungs and reversed some of the damage caused by fibrosis to those organs.
  14. Integrin Antagonist

    TR-14035 is a dual antagonist of α4β7 and α4β1 integrins.
  15. α4β1/α9β1 inhibitor

    R-BC154 is a high affinity fluorescent α4β1/α9β1 inhibitor.
  16. α1β1 inhibitor

    Highly potent integrin α1β1 inhibitor (IC50 = 0.8 nM for α1β1 binding to type IV collagen). Selective for α1β1 over α2β1, αIIbβ3, αvβ3, α4β1, α5β6, α9β1 and α4β7. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitumor efficacy in a synergistic mouse model of Lewis lung carcinoma; blocks human melanoma growth in nude mice.
  17. Integrin Inhibitor

    TCS2314 is a integrin very late antigen-4 (VLA-4; α4β1) antagonist with IC50 value of 4.4 nM.
  18. Fluorescent ligand

    LDV FITC is a fluorescent ligand for α4β1 (VLA-4).
  19. GpIIb/IIIa antagonist

    GR 144053 trihydrochloride is a potent and selective platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist.
  20. glycoprotein IIb/IIIa antagonist

    Eptifibatide is a potent glycoprotein IIb/IIIa antagonist (GPIIb/IIIa; Kd = 120 nM) that inhibits platelet aggregation.
  21. α2β1 integrin inhibitor

    BTT-3033 is a α2β1 integrin inhibitor.
  22. α9β1/α4β1 integrin inhibitor

    BOP sodium salt is a novel dual alpha9beta1/alpha4beta1 integrin inhibitor.
  23. LFA-1 modulator

    BIRT-377 is a negative allosteric modulator of LFA-1.
  24. VLA-4 inhibitor

    BIO-5192 is a small molecule VLA-4 inhibitor.
  25. LFA-1 Antagonist

    BMS-688521 is a small molecule antagonist of leukocyte function associated antigen-1 (LFA-1).
  26. LFA-1 inhibitor

    RWJ 50271 is a selective inhibitor of LFA-1 (lymphocyte function-associated antigen-1).
  27. Integrin alpha4beta1 inhibitor

    BIO-1211 is an integrin alpha4beta1 inhibitor.
  28. LFA-1/ICAM-1 interaction inhibitor

    A 286982 is a potent inhibitor of the LFA-1/ICAM-1 interaction with IC50 valueof 44 and 35 nM in LFA-1/ICAM-1 binding and LFA-1-mediated cell adhesion, respectively.
  29. LFA-1 antagonist

    Lifitegrast (SAR 1118) is an integrin lymphocyte function-associated antigen-1 (LFA-1) antagonist; inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM.
  30. platelet glycoprotein IIb/IIIa antagonist

    Fradafiban is a nonpeptide platelet glycoprotein IIb/IIIa antagonist, which binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM.
  31. α5β1-integrin ligand

    c(phg-isoDGR-(NMe)k) is a selective and potent α5β1-integrin ligand with an IC50 of 2.9 nM.
  32. α4β1/α4β7 integrin antagonist

    Zaurategrast ethyl ester (CDP323), the ethyl ester prodrug of CT7758, is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders.
  33. integrin αvβ3 antagonist

    Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist with binding affinity of 18 nM, as s novel anticancer agent.
  34. αvβ3 integrin antagonist

    MK-0429 (L-000845704) is an orally active, potent, selective and nonpeptide αvβ3 integrin antagonist with an IC50 of 80 nM.
  35. integrin α5β1 antagonist

    ATN-161 is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model.
  36. integrin α5β1 antagonist

    ATN-161 trifluoroacetate salt is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model.
  37. αVβ3 integrin inhibitor

    Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
  38. α4 integrin receptor inhibitor

    Carotegrast is an orally available α4 integrin receptor inhibitor with anti-inflammatories activities.
  39. integrin-ligand interactions inhibitor

    RGD peptide (GRGDNP) acts as an inhibitor of integrin-ligand interactions and plays an important role in cell adhesion, migration, growth, and differentiation.

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