Ion Channels



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Catalog No. Product Name Application Product Information
A12761 SALE

(+)-MK 801 Maleate

NMDA receptor antagonist
(+)-MK 801 is a potent antagonist of NMDA with Ki value of 30.5nM.
A10006 SALE

(-)-Huperzine A

GluR inhibitor
(-)-Huperzine A is a naturally occurring sesquiterpene alkaloid compound found in the firmoss Huperzia serrata.
A13435 SALE

(-)-MK 801 maleate

NMDA receptor antagonist.
(-)-MK 801 maleate acts as a potent, selective, and non-competitive NMDA receptor antagonist. It acts by binding to a site located within the NMDA associated ion channel.
A11234 SALE

A 803467

Sodium channel Blocker
A 803467 is a selective blocker of NaV1.8 channels (IC50 values are 8, 2450, 6740, 7340 and 7380 nM for hNaV1.8, hNaV1.3, hNaV1.7, hNaV1.5 and hNaV1.2 channels respectively).
A12353 SALE

A 967079

TRPA1 channel blocker
A 967079 is a selective TRPA1 channel blocker (IC50 values are 67 and 289 nM at human and rat TRPA1 receptors respectively).
A13539

A-582941

α7 nAChR agonist
A-582941 is a selective AChR a7 partial agonist. It exhibits high affinity for both rat and human a7 receptors (Ki values are 10.8 and 16.7 nM, respectively).
A11290

A-867744

modulator of α7 nAChRs
A-867744 is a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor.
A11314

AMG 073 (Cinacalcet)

calcimimetic compound
AMG-073 (Cinacalcet) represents a new class of compounds for the treatment of hyperparathyroidism.
A10219 SALE

AMG-073 HCl (Cinacalcet HCl)

CaSR activator
AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism known as calcimimetics, which reduce parathyroid hormone (PTH) synthesis and secretion by increasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium.
A10064 SALE

Amiloride HCl

Na+ channel blocker
Amiloride hydrochloride is a Na+ channel blocker, also inhibits TRPP3 channels and Na+/H+ exchanger (NHE).
A11728 SALE

Amiloride hydrochloride dihydrate

-
Amiloride hydrochloride dihydrate is a potent epithelial sodium channel blocker and selective low threshold (T-type) calcium channel protein inhibitor (KD=30μM).
A10068 SALE

Amlodipine

L-type calcium channel blocker
Amlodipin is L-type calcium channel blocker that displays antihypertensive properties. It inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease.
A10069

Amlodipine besylate (Norvasc)

L-type calcium channel blocker
Amlodipine-besylate is L-type calcium channel blocker that displays antihypertensive properties. It inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease.
A11405

Astragaloside A

Ca2+ signaling modulator
Astragaloside A is a novel regulator of HIF-1α and angiogenesis through the PI3K/Akt pathway in HUVECs that are exposed to hypoxia.
A11219

Azelnidipine

calcium channel blocker
Azelnidipine is a calcium blocker that attenuates liver fibrosis and may increase antioxidant defence. that attenuates liver fibrosis and may increase antioxidant defence.
A13989 SALE

BAPTA tetrapotassium

Selective calcium chelator
BAPTA tetrapotassium is a selective calcium chelator with greater affinity for Ca2+ than Mg2+.
A14023 SALE

BAPTA/AM

Selective calcium chelator
BAPTA/AM, an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures.
A11730

Benidipine hydrochloride

-
Benidipine hydrochloride is a long-acting T-type calcium channel blocker, on blood pressure and renal function in hypertensive patients with diabetes mellitus.
A13784

Bretazenil

GABAA agonist
Bretazenil, a benzodiazepine receptor partial agonist, as an adjunct in the prophylactic treatment of OP poisoning.
A13723 SALE

CFTR-Inhibitor-II

-
CFTR inhibitor II, also known as GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (Ki = 4.3 uM).
A15791

CGS19755

NMDA antagonist
CGS 19755 (cis-4-phosphonomethyl-2-piperidine carboxylic acid) was found to be a potent, stereospecific inhibitor of N-methyl-D-aspartate (NMDA)-evoked, but not KCl-evoked, [3H] acetylcholine release from slices of the rat striatum.
A10215 SALE

Cilnidipine

Calcium channel blocker
Cilnidipine is a dual blocker of L-type voltage-gated calcium channels in vascular smooth muscle and N-type calcium channels in sympathetic nerve terminals that supply.
A11206 SALE

CK-1827452 (Omecamtiv mecarbil)

Myosin activator
CK-1827452 is a selective cardiac specific myosin activator.
A11746 SALE

Clevidipine

Calcium channel blocker
Clevidipine is a dihydropyridine calcium channel blocker indicated for the reduction of blood pressure when oral therapy is not feasible or not desirable.
A10309

Diethylstilbestrol

-
Diethylstilbestrol is a synthetic nonsteroidal estrogen that was first synthesized in 1938. It is also classified as an endocrine disruptor.

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